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The Dangers of Combining Ativan (Lorazepam) and Alcohol

Written by Shannon Weir, RN | Updated on Feb 5, 2024

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Medically reviewed by Sara Kaylor, LCDC, LPC

The Dangers of Combining Ativan (Lorazepam) & Alcohol

The intersection where prescription medication meets alcohol consumption is often a dangerous crossroad. Ativan (lorazepam), a widely prescribed benzodiazepine, is no exception, and its mixture with alcohol is particularly perilous. Despite Ativan’s legitimate medical uses, it holds a potential for abuse, with alcohol often being the co-substance of choice, a combination that can steer users toward life-threatening consequences.

How Alcohol Affects the Brain

When ingested, alcohol swiftly navigates through our digestive tract, entering the bloodstream and ultimately reaching the brain. Here, it plays a dual role with neurotransmitters: it amplifies the inhibitory effects of GABA (gamma-aminobutyric acid) and dampens the excitatory influence of glutamate on NMDA receptors. The result is a notable slowdown in brain activity marked by a decrease in excitability. Furthermore, alcohol elevates dopamine levels, fueling a cycle of pleasure and potential addiction.

Understanding Ativan (Lorazepam)

Ativan, known generically as lorazepam, belongs to a class of medications called benzodiazepines, which are central nervous system depressants. These drugs have a sedative effect, but their influence on the brain and body is multifaceted and profound.

Ativan and GABA

Ativan operates primarily by enhancing the effects of GABA, the chief inhibitory neurotransmitter in the brain. It binds to GABA-A receptors, increasing GABA’s affinity for its receptor. This action amplifies GABA’s natural calming effects, which leads to a reduction in neuronal overactivity associated with anxiety, seizures, and other conditions. The efficacy of Ativan in managing anxiety is due to its ability to produce a tranquilizing effect, lowering the physiological and psychological responses to stress.

The Sedative-Hypnotic Effect of Ativan

The sedative-hypnotic properties of Ativan account for its effectiveness in treating insomnia in the short term. By slowing down the central nervous system, Ativan facilitates the onset of sleep and can help maintain sleep through the night, though it is not generally recommended for long-term treatment of sleep disorders due to the risk of dependency.

Muscle Relaxation and Anticonvulsant Qualities of Ativan

Beyond its sedative effects, Ativan also has muscle relaxant and anticonvulsant properties. These make it valuable in settings where muscle spasms or seizures are a concern, such as in the treatment of epilepsy or during certain medical procedures. It can be used to relieve muscle tension and prevent the spread of seizure activity in the brain.

Anxiolysis and Preoperative Sedation

One of the hallmark uses of Ativan is in anxiolysis, or the reduction of anxiety. This makes it a common pre-medication before surgical procedures—not only does it calm the patient, but it also has amnesic effects, which means the patient is less likely to remember the distressing aspects of the procedure.

Ativan’s Duration of Effect

Ativan has an intermediate duration of action compared to other benzodiazepines. This means it starts working relatively quickly, and its effects can last for a reasonable amount of time without lingering too long in the system. This balance is part of why it’s favored for certain applications, such as acute anxiety relief and preoperative sedation.

Risks and Side Effects of Ativan (Lorazepam)

The calming effects of Ativan come with potential risks and side effects. Common side effects include dizziness, weakness, and unsteadiness, particularly in older adults, who are more susceptible to benzodiazepine-induced impairments. Prolonged use can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

 

Ativan’s effectiveness in providing rapid relief for anxiety and seizures makes it a valuable pharmaceutical tool, but its power must be wielded with caution. Medical professionals prescribe it with the understanding that the very effects that make it therapeutic can also lead to abuse and adverse reactions, especially when combined with other CNS depressants like alcohol.

 

In the realm of mental health and neurology, Ativan is thus a potent ally against acute disturbances in brain function, but it is not without its challenges and potential for misuse. Its calming effects must always be balanced against the risks of sedation, dependency, and the amplified dangers when mixed with substances like alcohol.

The Dangers of Mixing Ativan and Alcohol

Combining Ativan (lorazepam) and alcohol can set the stage for a perilous interaction with the potential to impair both mind and body. When these two substances meet in the bloodstream, the effects are more than just additive—they compound, leading to an intensified experience of side effects that can jeopardize one’s health and safety.

Amplified CNS Depression

Both Ativan and alcohol are central nervous system depressants, and when used in concert, they significantly enhance each other’s effects. This interaction typically results in heightened dizziness, pronounced drowsiness, and a substantial decrease in cognitive functioning. The ability to concentrate becomes severely compromised, and this can impact all areas of one’s daily life, from the simplicity of daily tasks to the complexity of decision-making processes.

Impaired Mental Functions and Judgment

The cognitive impairments from mixing Ativan with alcohol are particularly troubling. Users may find their thinking clouded and judgment skewed. This can lead to poor decision-making and risky behaviors, potentially resulting in actions that might never be considered under normal circumstances. This impairment in judgment is especially dangerous when it comes to activities that require mental alertness, such as driving or operating machinery, where the stakes include not just the individual’s safety but also the safety of others.

Necessary Precautions

Given these risks, it is crucial to avoid alcohol while being treated with Ativan. Even the recommended dose of Ativan, when combined with alcohol, can lead to dangerous outcomes. Adhering strictly to the prescribed amount is essential, and one should remain vigilant regarding how the medication affects personal functioning. The sedative effects can be surprisingly potent, and the individual response can vary greatly.

 

To navigate the risks associated with Ativan, absolute transparency with one’s healthcare team and a commitment to avoiding alcohol are non-negotiable. The consequences of mixing Ativan with alcohol cannot be overstated; they can impair the ability to perform even simple tasks and alter mental acuity. It is a blend that must be avoided to ensure safety and well-being while under the therapeutic care of Ativan.

Preventive Measures and Recovery

The most straightforward prevention strategy is clear: avoid alcohol when taking Ativan. For those struggling with substance abuse, whether it be Ativan, alcohol, or other substances, seeking help is crucial. Recovery programs offer safe detoxification and support for a journey back to health and sobriety.

 

If you or someone you love is grappling with addiction to Ativan, alcohol, or both, Gallus Medical Detox Centers offers a pathway to recovery through medically supervised detox. Our personalized care and medical expertise provide a foundation for a safe and dignified journey to sobriety. We invite you to take the crucial first step by reaching out to us and utilizing our self-assessment tool, designed to help you understand the level of care needed. Take action today. Contact Gallus Medical Detox Centers to embark on the road to a healthier, substance-free life.  Call us at 866-272-5978.

 

FAQ About Ativan and Alcohol

What is Ativan, and why is it prescribed?

Ativan, known generically as lorazepam, is a prescription benzodiazepine used to treat anxiety disorders, insomnia, seizures, and as sedation before medical procedures. It works by enhancing the effects of GABA, a neurotransmitter that calms brain activity.

 

Why is mixing Ativan with alcohol dangerous?

Both Ativan and alcohol are central nervous system depressants. When taken together, they can dangerously enhance each other’s effects, leading to an increased risk of severe drowsiness, impaired motor control and judgment, and potentially overdose.

Can you drink alcohol if you’re taking Ativan?

No, it is strongly advised not to drink alcohol while taking Ativan. Alcohol can exacerbate the sedative effects of Ativan, significantly increasing the risk of adverse reactions and overdose.

How long after taking Ativan can you safely consume alcohol?

Alcohol should be avoided until Ativan is fully metabolized and cleared from your system, which can vary based on dosage, frequency of use, and individual metabolism. It is best to consult with a healthcare provider to determine when it is safe to consume alcohol after stopping Ativan.

Can Ativan be used to treat alcohol withdrawal?

Yes, Ativan is sometimes used in a medical setting to manage the symptoms of alcohol withdrawal due to its ability to reduce anxiety and prevent seizures, which can occur during withdrawal. However, this should only be done under strict medical supervision.

What should you do if you’ve mixed Ativan and alcohol?

If you or someone else has mixed Ativan and alcohol, it is crucial to seek medical attention immediately, even if symptoms seem mild. The combined effects can escalate quickly and may become life-threatening.

Are there any long-term effects of mixing Ativan with alcohol?

Repeatedly mixing Ativan with alcohol can lead to long-term health consequences, including an increased risk of developing an addiction, persistent cognitive and motor impairment, and potential damage to the liver and other organs.

How can someone get help if they’re struggling with addiction to Ativan and alcohol?

Professional treatment from addiction services like Gallus Medical Detox Centers is often necessary to safely detox and recover from substance abuse. A healthcare provider can offer guidance on treatment options, and support groups can provide ongoing support.

Is it ever safe to take Ativan if you have a history of alcoholism?

If you have a history of alcoholism, you should inform your healthcare provider before taking Ativan. They may prescribe an alternative treatment to avoid the risks associated with potential misuse and interactions with alcohol.

References

  1. The unhealthy mix between alcohol and mental health  | Camden and Islington NHS Foundation Trust. (n.d.). https://www.candi.nhs.uk/news/unhealthy-mix-between-alcohol-and-mental-health
  2. Lorazepam: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a682053.html
  3. Tan, K. R., Rudolph, U., & Lüscher, C. (2011). Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends in Neurosciences, 34(4), 188–197. https://doi.org/10.1016/j.tins.2011.01.004
  4. Ghiasi, N. (2023, January 31). Lorazepam. StatPearls – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK532890/
  5. Professional, C. C. M. (n.d.). Anxiolytics. Cleveland Clinic. https://my.clevelandclinic.org/health/treatments/24776-anxiolytics
  6. Website, N. (2023, July 10). Side effects of lorazepam. nhs.uk. https://www.nhs.uk/medicines/lorazepam/side-effects-of-lorazepam/
  7. Drug Interaction Report: Ativan, Alcohol (contained in alcoholic beverages). (n.d.). Drugs.com. https://www.drugs.com/interactions-check.php?drug_list=1488-899,1034-14582

Shannon Weir, RN

Shannon Weir, RN is the Chief Nursing Officer at Gallus Medical Detox Centers. She has been a Registered Nurse for 30 years, Shannon’s experience ranges from critical care to flight nursing, medical detox, sexual assault exams, and SWAT nursing. Shannon has been with Gallus Medical Detox Centers since 2010 and is a vital part of our organization.

Last medically reviewed on November 12, 2023

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