Written by Steve Carleton | Updated on Aug 3, 2023
The Dangers Of Combining Xanax & Lexapro
Xanax, or alprazolam, is a benzodiazepine that is frequently prescribed for anxiety and panic disorders. Lexapro, with the generic name escitalopram, is a type of selective serotonin reuptake inhibitor (SSRI) and is typically used to treat depression and anxiety disorders. Both Xanax and Lexapro, in their respective ways, may alleviate anxiety symptoms and improve mood, but their concurrent use can lead to a plethora of serious complications and should only be done under careful medical supervision.
Increased Risk of Over-sedation From Xanax and Lexapro
If you’ve been prescribed either of these drugs, you might know that Xanax can cause drowsiness and slow down your reaction time. Combining it with Lexapro may enhance these effects, leading to over-sedation. This excessive sedation can significantly affect individuals who need to be alert, like drivers or those operating heavy machinery, as it can lead to accidents or serious injuries.
Patients with a history of substance use or who are in the process of recovery from substance use disorders are at a heightened risk of over-sedation due to Xanax and Lexapro. Withdrawal from alcohol, sedatives, opiates, or stimulants can exacerbate the sedative effects and should be a factor when deciding on a course of medication.
Cognitive and Motor Impairment
Cognitive and motor impairments are common side effects of Xanax, and combining it with Lexapro can amplify these effects. Such impairments can affect an individual’s daily functioning and quality of life. In severe cases, this combination can lead to confusion, lack of coordination, and a decline in motor skills, increasing the risk of falls and other accidents, especially in the elderly.
Liver and Kidney Damage from Xanax and Lexapro
While both Xanax and Lexapro are generally safe for the liver and kidneys at therapeutic doses, prolonged use or abuse, particularly when combined, can strain these organs. Both drugs are metabolized in the liver and excreted by the kidneys. Individuals with pre-existing liver or kidney conditions are at a higher risk of damage or toxicity when these drugs are combined.
Heart Problems Associated with Xanax and Lexapro
Xanax can cause changes in heart rate and blood pressure. Concurrent use with Lexapro, which has also been associated with heart-related side effects, can lead to significant cardiovascular issues. These can range from palpitations and irregular heart rhythms to more severe conditions such as myocardial infarction (heart attack) or stroke. It’s especially critical for individuals with pre-existing heart conditions to use this drug combination with caution.
Overlapping Side Effects
Taking Lexapro can intensify some of the side effects of Xanax, such as drowsiness, dizziness, and confusion. Simultaneously, Xanax can exacerbate some of the common side effects of Lexapro, such as nausea, dry mouth, and constipation. The simultaneous use of these two drugs can also heighten the risk of psychological symptoms such as depression, unusual mood changes, suicidal thoughts, and increased anxiety.
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References:
- Alprazolam: MedlinePlus drug information. (n.d.-b). https://medlineplus.gov/druginfo/meds/a684001.html
- Escitalopram: MedlinePlus drug information. (n.d.-b). https://medlineplus.gov/druginfo/meds/a603005.html
- Verster, J. (2002). Effects of Alprazolam on Driving Ability, Memory Functioning and Psychomotor Performance A Randomized, Placebo-controlled Study. Neuropsychopharmacology, 27(2), 260–269. https://doi.org/10.1016/s0893-133x(02)00310-x
- MRPharmS, H. M. B. (2023, March 13). Xanax (alprazolam). https://www.medicalnewstoday.com/articles/drugs-xanax
- Lexapro and Xanax interactions Checker. (n.d.). Drugs.com. https://www.drugs.com/drug-interactions/lexapro-with-xanax-1013-565-133-54.html
Steve Carleton
Steve worked in the Department of Veterans Affairs for 10 years. He is a PTSD and substance use disorder expert with over 14 years of experience in and around addiction. Steve is also an Adjunct Professor at the University of Denver’s Graduate School of Social work. He teaches cognitive behavioral therapies, Motivational Interviewing, assessment skills using DSM-5, amongst others.
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