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The Risks of Mixing Methadone and Xanax (alprazolam)

Written by Shannon Weir, RN | Updated on Nov 9, 2023

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Medically reviewed by Shannon Weir, RN

The Dangers of Mixing Methadone and Xanax

When it comes to medication, the importance of following prescribed guidelines cannot be stressed enough. This is particularly crucial when combining powerful drugs like Methadone and Xanax. Individually, these medications serve valuable purposes in healthcare. Methadone is often prescribed to treat opioid addiction and sometimes for pain, while Xanax is used primarily to treat anxiety and panic disorders. However, when taken together, these drugs can interact in potentially lethal ways.

Understanding Methadone

Methadone is best known for its role in treating opioid addiction. When used as part of a comprehensive treatment program, Methadone can help individuals reduce or quit their use of heroin or other opiates. It acts by blocking the high these drugs produce, reducing the euphoric sensations, and helping mitigate withdrawal symptoms. This allows for a smoother, more controlled path to recovery.

Methadone maintenance is not meant to be used to get high but is designed to help individuals stop taking other opiates, such as prescription painkillers and heroin. Individuals who use Methadone to stop other drug use are supposed to stop after the withdrawal period. However, most individuals do not stop their Methadone use and, as a result, ultimately end up trading one addiction for another. Another concern with Methadone is that it remains active in the body for up to about 60 hours, during which time individuals may take more of the medication or take other medication – which will put them at risk for overdose. Statistics show that between 1999 and 2005, Methadone related deaths rose 600 percent: from 786 deaths in 1999 to 4,462 deaths in 2005.

Apart from its role in addiction treatment, Methadone is also prescribed as a pain reliever. It can be used to treat moderate to severe pain, especially in cases where pain is chronic. However, due to its potential for misuse and associated risks, its prescription for pain management is usually reserved for situations where other pain medications have proven ineffective.

It’s worth noting that while Methadone can be instrumental in opioid addiction treatment and pain management, it’s not without its challenges. Like other opioids, Methadone can lead to dependency and has a risk of overdose, especially when not used as prescribed or when mixed with other depressants like alcohol or benzodiazepines, such as Xanax.

Understanding the nature and properties of Methadone is essential, not only for those who are prescribed it but also for their families and the community at large. Being informed is the first step towards ensuring safe and effective use.

Understanding Xanax

Xanax, which is the brand name for alprazolam, is a benzodiazepine. Benzodiazepines are a class of medications primarily known for their calming and sedative effects. Here’s what you need to know about Xanax:

Xanax is most commonly prescribed to treat generalized anxiety disorder (GAD) and panic disorders. It acts on the brain by enhancing the effects of a specific neurotransmitter called gamma-aminobutyric acid (GABA). This results in a calming effect, helping reduce symptoms of anxiety and panic attacks.

One of the characteristics of Xanax is its rapid onset of action, which makes it particularly effective for relieving acute symptoms of anxiety. However, due to its potency and potential for dependence, it’s generally prescribed for short-term use or as-needed basis.

Just like other benzodiazepines, Xanax can lead to physical and psychological and physical dependence, especially when used in higher doses or for extended periods. This means that if a person tries to reduce or stop usage abruptly, they might experience withdrawal symptoms, which can be severe.

Apart from its potential for dependency, Xanax also carries a risk of overdose, especially when mixed with other CNS depressants like opioids or alcohol. Overdose symptoms can range from extreme drowsiness to respiratory depression and even death.

In some cases, Xanax might be prescribed off-label for other conditions, such as insomnia or symptoms of premenstrual syndrome (PMS). However, these are not the primary indications for the drug.

Xanax becomes fully active within 10 to 15 minutes. It can also cause an individual to literally pass out and fall over. Moreover, prolonged use of Xanax can result in a build-up of the drug in the body. In turn, this can lead to other health issues, including liver and kidney failure. In fact, reports from the National Institute on Drug Abuse show that close to 125,000 people go to the emergency room each year as a result of Xanax abuse. Statistics also show that approximately 100,000 people report using Xanax with other drugs and/or alcohol.

While Xanax offers significant therapeutic benefits for those suffering from anxiety or panic disorders, it’s essential to approach its usage with caution. Being informed about its properties, potential risks, and consulting regularly with a healthcare professional is vital to ensure its safe and effective use.

The Risks of Mixing Methadone and Xanax

First of all, the combination of Xanax and Methadone can be deadly. Yet, you may have heard that the combination of the two drugs increases the euphoria and is similar to the same feeling as Heroin. However, taking Xanax and Methadone together can result in overdose. Xanax is a sedative from the class of drugs known as benzodiazepines and is often used to treat anxiety. When combined with Methadone, individuals may experience dizziness and drowsiness, difficulty concentrating, and impaired judgment. Moreover, both drugs are central nervous system depressants, and the danger lies in the fact that the brain can forget to tell the heart and lungs to work, which means that you could stop breathing.

Both Methadone and Xanax have depressive effects on the central nervous system (CNS). This means they can slow down brain activity and affect how our CNS regulates vital functions. When combined, their effects can be magnified, leading to several critical risks.

One of the primary dangers of mixing Methadone and Xanax is the slowing down or suppression of respiratory function. This can decrease oxygen intake, which is vital for our body’s cells and organs. Respiratory depression can lead to hypoxia, a condition where the body doesn’t get enough oxygen, which can be fatal.

Severe symptoms of CNS depression may include:

  • Slowed breathing or increased heart rate
  • Blue or gray tint to the skin, lips, or nails (cyanosis)
  • Decreased level of consciousness or extreme drowsiness

If left untreated, respiratory depression can lead to the following complications:

  • Hypoxia: This condition arises when there’s insufficient oxygen reaching the body’s tissues. Hypoxia can lead to organ dysfunction and damage.
  • Respiratory Failure: In severe cases, the lungs might fail to perform their gas exchange function, leading to a buildup of carbon dioxide in the blood.
  • Death: Severe respiratory depression, especially when caused by drug interactions, can be fatal if not addressed promptly.

Precautionary Measures and Considerations

If you’re on either Methadone, Xanax, or both, it’s imperative to have an open dialogue with your doctor. They might adjust the dosage, prescribe alternatives, or suggest more frequent monitoring to ensure safe consumption.

Combining these medications with alcohol can amplify their depressive effects on the CNS. Similarly, self-medicating or adjusting the dosage without a doctor’s guidance can lead to overdosing and severe complications.

These medications can cause dizziness, drowsiness, and impaired judgment. This could result in accidents if one is driving or operating heavy machinery. Always gauge how the drugs affect you and refrain from such activities if you feel impaired.

Always provide your doctor with a comprehensive list of all the medications, vitamins, and herbs you’re consuming. This will help them identify any potential drug interactions and advise you accordingly.

If you ever feel the need to stop using these medications, consult your doctor first. Abrupt cessation can lead to withdrawal symptoms or other complications.

Help is Available at Gallus

The combination of Methadone and Xanax, while beneficial when used correctly for their respective medical purposes, can pose grave risks when mixed. The potential dangers of respiratory depression, coma, and even death cannot be ignored. It is imperative for individuals to be well-informed and cautious, and consult regularly with healthcare professionals to ensure the safe and effective use of these medications.

If you or a loved one are facing challenges with opioid addiction or any other form of addiction, there is help available. Gallus Medical Detox specializes in providing advanced medical detox treatments tailored to individual needs in a comfortable, compassionate, and safe environment. Remember, addiction is not a sign of weakness—it’s a complex health issue that requires professional care and support.

If you’re uncertain about the extent of an addiction or its impact, Gallus Medical Detox offers a self-assessment tool that can guide you. Recovery begins with understanding.

Take the first step towards a brighter, addiction-free future. Reach out to Gallus Medical Detox, either by calling directly or taking the self-assessment on their website. Your journey to recovery is one call or click away. Call 866-272-5978 today.

FAQs

What is Methadone used for?

Methadone is primarily used for opioid addiction treatment, helping individuals reduce or quit their use of heroin or other opiates. It’s also prescribed for pain management, especially in cases where the pain is chronic and other pain medications are ineffective.

How does Xanax work?

Xanax, or alprazolam, is a benzodiazepine. It works by enhancing the effects of a neurotransmitter in the brain called gamma-aminobutyric acid (GABA), which results in a calming effect. It’s primarily prescribed to treat generalized anxiety disorder (GAD) and panic disorders.

Why is mixing Methadone and Xanax dangerous?

Both Methadone and Xanax are central nervous system (CNS) depressants. When combined, their depressive effects can be magnified, leading to serious side effects like respiratory depression, coma, or even death.

What are the signs of respiratory depression?

Signs to watch for include extreme drowsiness, shallow or slowed breathing, dizziness, confusion, bluish tint to the skin, especially around lips or fingertips, and inability to stay awake. If you or someone you know exhibits these signs after taking these medications seek medical attention immediately.

Can alcohol exacerbate the effects of these medications?

Yes, combining these medications with alcohol can amplify their depressive effects on the CNS, leading to heightened risks of overdose and respiratory depression.

Are there any other medications or substances that can interact negatively with Methadone or Xanax?

Yes, several medications and substances can interact with these drugs. Always provide your doctor with a comprehensive list of all you’re taking, including over-the-counter drugs, vitamins, and herbs, to identify potential drug interactions.

What should I do if I believe someone is experiencing respiratory depression due to drug interactions?

Seek emergency medical help immediately. Respiratory depression is a life-threatening condition that requires prompt intervention.

References

  1. World Health Organization. (2009a). Methadone maintenance treatment. Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Settings – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK310658/
  2. Methadone: MedlinePlus drug information. (n.d.-b). https://medlineplus.gov/druginfo/meds/a682134.html
  3. Alprazolam: MedlinePlus drug information. (n.d.-b). https://medlineplus.gov/druginfo/meds/a684001.html
  4. Jewett, B. E. (2023, July 24). Physiology, GABA. StatPearls – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK513311/
  5. Brett, J., & Murnion, B. (2015). Management of benzodiazepine misuse and dependence. Australian Prescriber, 38(5), 152–155. https://doi.org/10.18773/austprescr.2015.055
  6. McCance-Katz, E. F., Sullivan, L. E., & Nallani, S. C. (2010). Drug Interactions of Clinical Importance among the Opioids, Methadone and Buprenorphine, and Other Frequently Prescribed Medications: A Review. American Journal on Addictions, 19(1), 4–16. https://doi.org/10.1111/j.1521-0391.2009.00005.x
  7. Drug Interaction List: methadone, Xanax – Drugs.com. (n.d.). Drugs.com. https://www.drugs.com/interactions-check.php?drug_list=1578-0,133-54v
  8. Mukandala, G., Tynan, R., Lanigan, S., & O’Connor, J. (2016). The effects of hypoxia and inflammation on synaptic signaling in the CNS. Brain Sciences, 6(1), 6. https://doi.org/10.3390/brainsci6010006
  9. Pietrangelo, A. (2018, August 15). Understanding Central nervous system (CNS) depression: symptoms, treatment, and more. Healthline. https://www.healthline.com/health/depression/cns-depression

 

 

Shannon Weir, RN

Shannon Weir, RN is the Chief Nursing Officer at Gallus Medical Detox Centers. She has been a Registered Nurse for 30 years, Shannon’s experience ranges from critical care to flight nursing, medical detox, sexual assault exams, and SWAT nursing. Shannon has been with Gallus Medical Detox Centers since 2010 and is a vital part of our organization.

Last medically reviewed on October 20, 2023

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